Autologous stem cell transplant12/25/2023 ![]() ![]() These stem cells then return to the bone marrow where they regenerate and restore your red blood cells, white blood cell and platelets after about two weeks. The stem cells are thawed and painlessly returned into your bloodstream in a process similar to a blood transfusion. The third stage occurs immediately after the end of the chemotherapy. This means they need to be replaced with healthy stem cells. Because this treatment is intense, it wipes out the normal marrow stem cells. During an outpatient stem cell transplant, the patient undergoes the full course of treatment (pre-transplant evaluation, conditioning, infusion of their stem. This is known as graft versus host disease (GvHD). ![]() Graft versus host disease (GvHD) Sometimes, the transplanted cells recognise the recipients cells as 'foreign' and attack them. Or rarely, they collect a matched donor's stem cells. This is called an autologous stem cell transplant. Before your high dose chemotherapy, your team collects your stem cells. The second stage involves admitting you as an inpatient for high dose chemotherapy to try and kill the cancer cells. People receiving transplants of their own stem cells (autologous transplants) are also less likely to experience serious side effects. The chemotherapy has a good chance of killing the myeloma cells but it also kills the healthy stem cells in your bone marrow. These stem cells are separated from your blood using an outpatient procedure called apheresis and then frozen for storage. ![]() This involves receiving daily injections under the skin of a drug called G-CSF, which encourages the stem cells to enter the blood stream from the bone marrow where they usually reside. Stage oneįirstly, prior to chemotherapy or radiotherapy, the bone marrow is stimulated to produce an excess number of stem cells that enter your bloodstream. Stages of an autologous stem cell transplantĪn autologous stem cell transplant has three stages: stem cell stimulation and collection, high dose chemotherapy and stem cell infusion. These transplants are most commonly used for patients with myeloma or relapsed lymphoma. You'll meet with your care team frequently to watch for side effects and to monitor your body's response to the transplant.Why you might need an autologous stem cell transplantĪn autologous stem cell transplant is used to help your bolod counts recover after high dose chemotherapy. Your stem cells will be infused into your bloodstream, where they will travel to your bone marrow and begin creating new blood cells.Īfter your autologous stem cell transplant, you'll remain under close medical care. Talk with your doctor about what you can expect from your treatment. The cancer treatments used during the conditioning process carry a risk of side effects. The treatments you undergo depend on your disease and your particular situation. The current standard of care model for newly diagnosed fit multiple myeloma (NDMM) patients is the sequential treatment of induction, high dose melphalan, autologous stem cell transplantation. During the conditioning process, you'll receive high doses of chemotherapy or radiation therapy - or sometimes both treatments - to kill your cancer cells. Undergoing high doses of cancer treatment (conditioning). A machine filters out the stem cells and the rest of your blood is returned to your body.Ī preservative is added to your stem cells and then they're frozen and stored for later use. For stem cell collection, a needle is inserted into a vein in your arm to draw out your blood. An autologous stem cell transplant is also called an autologous bone marrow transplant. You'll receive medications that cause your stem cells to increase in number and to move out of your bone marrow and into your blood, where they can be easily collected.įiltering stem cells from your blood. An autologous stem cell transplant uses healthy blood stem cells from your own body to replace bone marrow that's not working properly. Taking medications to increase the number of stem cells in your blood.Undergoing an autologous stem cell transplant involves: An autologous stem cell transplant helps to replace the damaged bone marrow.Īn autologous stem cell transplant is most often used to treat: These treatments are likely to damage the bone marrow. Autologous stem cell transplants are typically used in people who need to undergo high doses of chemotherapy and radiation to cure their diseases. ![]()
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